As a self-publisher, you should learn a few conventions before you lay out your book
Take your level of computer savvy, patience, graphic design skills, and willingness to learn new software into account before you tackle doing your own book layout with a program like InDesign
The ultimate goal of any document is to be read, so avoid design treatments that impair readability
Just because you can put 37 fonts into your book layout doesn’t mean you should.
Make a quick brochure in any version of Word using columns.